Class
Thymosin Beta-4 Synthetic Fragment
Molecular Weight
4,963 Da
Half-life
Hours (multi-dose protocols studied)
Purity
≥98% (HPLC)
Form
Lyophilized powder
Storage
Lyophilized: −20°C; Reconstituted: 4°C
Reconstitution
Bacteriostatic water or sterile saline
Mechanism of action
TB-500 is a synthetic analogue of the conserved region of thymosin beta-4 — an endogenous actin-sequestering protein present in virtually all nucleated mammalian cells. The Ac-SDKP tetrapeptide within TB-500 is hypothesized to upregulate actin polymerization to promote cell migration, stimulate angiogenesis via VEGF pathway modulation, reduce local inflammation through NF-κB pathway downregulation, and activate stem cell differentiation in damaged tissue sites.
⚠️ For Research Use Only — described exclusively for in vitro and laboratory research by qualified researchers. Not for human or veterinary use. Informational only; does not constitute medical advice or imply efficacy in humans.
Research highlights
↑ VEGF
Angiogenesis via vascular endothelial growth factor
↓ NF-κB
Reduction in inflammatory cytokine cascade
Cardiac
Cardiomyocyte regeneration in MI models
Hair
Follicle stem cell activation — anagen extension
Research notes
- Wound healing: Multiple animal studies demonstrate accelerated dermal wound closure and reduced scar tissue formation.
- Cardiac: Murine MI models showed cardiomyocyte regeneration and measurable improvement in ventricular function.
- Tendon/ligament: In vitro studies show enhanced tenocyte migration and proliferation in response to TB-500.
- Hair follicle: Thymosin beta-4 shown to activate hair follicle stem cells and extend the anagen growth phase.
- Neuroprotection: CNS injury models suggest reduced neuroinflammation and partial functional recovery.
