Class
GH C-Terminal Fragment — Lipolytic, Non-anabolic
Molecular Weight
1,817.1 Da
Half-life
~30 minutes
Purity
≥98% (HPLC)
Form
Lyophilized powder
Storage
Lyophilized: −20°C; Reconstituted: 4°C
Reconstitution
Bacteriostatic water
Mechanism of action
AOD-9604 is a synthetic fragment corresponding to amino acids 177–191 of the human GH C-terminus with a stabilizing N-terminal tyrosine. This fragment retains the lipolytic properties attributed to full HGH but does not bind the GH receptor in a manner that triggers IGF-1 production or anabolic signaling. Research suggests activity via the beta-3 adrenergic receptor and hypothalamic regulation of fat metabolism.
⚠️ For Research Use Only — described exclusively for in vitro and laboratory research by qualified researchers. Not for human or veterinary use. Informational only; does not constitute medical advice or imply efficacy in humans.
Research highlights
0
IGF-1 elevation (distinct from full HGH)
↑ β3-AR
Beta-3 adrenergic receptor activity
Lipolytic
Fat breakdown without proliferative effects
Cartilage
Chondroprotective and repair properties observed
Research notes
- Selective lipolysis: Stimulates fat breakdown in adipocytes without proliferative or anabolic effects seen with full HGH.
- No IGF-1: Does not appear to raise IGF-1 in research subjects — important distinction for researchers studying selective fat loss.
- Obesity models: Multiple animal studies show significant reduction in body fat percentage without muscle loss.
- Cartilage: Some research suggests chondroprotective and cartilage regenerative effects via TGF-β modulation.
- Metabolic syndrome: Improvements in lipid profiles and insulin sensitivity observed alongside fat reduction.
