Class
Mod GRF 1-29 — Short-acting GHRH Analogue
Molecular Weight
3,367.9 Da
Half-life
~30 minutes
Purity
≥98% (HPLC)
Form
Lyophilized powder
Storage
Lyophilized: −20°C; Reconstituted: 4°C
Reconstitution
Bacteriostatic water
Mechanism of action
CJC-1295 without DAC (Modified GRF 1-29) is a 29-amino-acid GHRH fragment with four stabilizing amino acid substitutions that improve enzyme resistance compared to native GHRH 1-29. Without the DAC moiety, it does not bind albumin and has a half-life of ~30 minutes, enabling timed pulsatile GHRH stimulation that closely mimics the physiological pattern of endogenous GH secretion.
⚠️ For Research Use Only — described exclusively for in vitro and laboratory research by qualified researchers. Not for human or veterinary use. Informational only; does not constitute medical advice or imply efficacy in humans.
Research highlights
~30 min
Half-life — mimics physiological GHRH pulsatility
Pulsatile
Natural GH secretion pattern preserved
Low
Receptor desensitization risk vs continuous dosing
+Ipam
Classic pulsatile stack with Ipamorelin
Research notes
- Pulsatile design: Short half-life allows precise timing of GH pulses, useful for studying circadian and sleep-associated GH secretion.
- vs DAC version: Lacks the persistent IGF-1 elevation; allows cleaner measurement windows in research protocols.
- Minimal desensitization: Pulsatile use avoids chronic GHS-R1a downregulation concerns associated with DAC version.
- Synergy: Standard pairing with Ipamorelin for combined GHRH + GHRP action; well-documented amplification.
