Class
Body Protective Compound — Gastric Pentadecapeptide
Molecular Weight
1,419.5 Da
Half-life
Hours (parenteral); stable in gastric juice
Purity
≥99% (HPLC)
Form
Lyophilized powder
Storage
Lyophilized: −20°C; Reconstituted: 4°C
Reconstitution
Bacteriostatic water
Mechanism of action
BPC-157 is a 15-amino-acid synthetic fragment derived from a region of human gastric juice proteins. Research models propose activity through upregulation of growth hormone receptor expression, activation of the FAK-paxillin pathway supporting cell migration, modulation of the nitric oxide system for vascular effects, interaction with dopaminergic and serotonergic systems, and direct cytoprotective effects on gastrointestinal mucosal cells.
⚠️ For Research Use Only — described exclusively for in vitro and laboratory research by qualified researchers. Not for human or veterinary use. Informational only; does not constitute medical advice or imply efficacy in humans.
Research highlights
GI
Accelerated gastric ulcer and IBD healing in rodent models
Tendon
Superior Achilles tendon healing vs controls
CNS
Partial motor recovery in dopamine-lesioned models
Systemic
Cytoprotective effects: liver, kidney, cardiac models
Research notes
- GI integrity: Extensive rodent models show accelerated healing of gastric ulcers, intestinal anastomoses, and chemically-induced colitis.
- Tendon-to-bone: Demonstrated superior healing of Achilles tendon transection in rat models vs untreated controls.
- CNS: Studies in 6-OHDA dopamine-lesioned rats show partial recovery of motor function, suggesting dopaminergic modulation.
- Bone healing: Fracture union acceleration observed in tibial fracture models alongside increased bone mineral density markers.
- Angiogenesis: Upregulation of VEGF and nitric oxide pathways linked to observed vascular-supportive effects.
