Class
Nicotinamide Adenine Dinucleotide — Essential Coenzyme
Molecular Weight
663.4 Da
Half-life
Cellular turnover ~1 hour; systemic varies
Purity
≥98% (HPLC)
Form
Lyophilized powder
Storage
Lyophilized, protected from light and moisture at −20°C
Reconstitution
Sterile water or PBS (pH 7.4)
Mechanism of action
NAD+ is an essential coenzyme found in all living cells, participating in hundreds of metabolic redox reactions as an electron carrier. In longevity and cellular health research, NAD+ serves as a substrate for Sirtuins (SIRT1–7, NAD+-dependent deacetylases), PARP enzymes (DNA damage repair), and CD38/CD157 (cyclic ADP-ribose signaling). NAD+ levels decline markedly with age — by 50%+ in many tissues between young adulthood and middle age.
⚠️ For Research Use Only — described exclusively for in vitro and laboratory research by qualified researchers. Not for human or veterinary use. Informational only; does not constitute medical advice or imply efficacy in humans.
Research highlights
−50%
Age-related NAD+ decline in many tissues
SIRT1
Sirtuin activation: DNA repair, mitochondrial function
PARP
DNA damage repair enzyme substrate
Muscle
Improved function in aged mouse models
Research notes
- Age-related decline: NAD+ levels fall 50%+ between young adulthood and middle age in animal models of aging.
- Sirtuin activation: SIRT1 and SIRT3 activation linked to improved mitochondrial biogenesis, reduced inflammation, and enhanced DNA repair.
- Muscle function: Aged mice treated with NAD+ precursors showed improved muscle strength, endurance, and reduced fatigue.
- Neuroprotection: Neuronal models show NAD+ replenishment protects against degeneration and supports axonal integrity.
- PARP activation: Adequate NAD+ supports genomic stability under oxidative and genotoxic stress conditions.
