Class
NNMT Inhibitor (Nicotinamide N-methyltransferase)
Molecular Weight
193.2 Da (small molecule)
Half-life
Under investigation
Purity
≥98% (HPLC)
Form
Powder
Storage
−20°C, dry, protected from moisture
Reconstitution
DMSO or sterile water (partial solubility)
Mechanism of action
5-Amino-1-methylquinolinium (5-Amino-1MQ) is a competitive inhibitor of NNMT — an enzyme overexpressed in adipose tissue in obesity that converts nicotinamide to 1-methylnicotinamide while consuming SAM (S-adenosyl methionine). By inhibiting NNMT, 5-Amino-1MQ increases nicotinamide pool availability (NAD+ precursors), elevates cellular SAM supporting methylation reactions, reduces adipogenesis, and enhances energy expenditure through improved mitochondrial function.
⚠️ For Research Use Only — described exclusively for in vitro and laboratory research by qualified researchers. Not for human or veterinary use. Informational only; does not constitute medical advice or imply efficacy in humans.
Research highlights
↑ NAD+
Increased cellular NAD+ via nicotinamide pool
↓ NNMT
Enzyme overexpressed in obese adipose tissue
Anti-adip
Reduced lipid accumulation and adipocyte differentiation
SIRT1
Downstream sirtuin activation via NAD+ elevation
Research notes
- Adipocyte research: In vitro models show reduced lipid accumulation and pre-adipocyte differentiation upon NNMT inhibition.
- In vivo fat reduction: Animal models demonstrate reduced fat mass without caloric restriction via NNMT inhibition.
- NAD+ elevation: Downstream increase in cellular NAD+ and SIRT1 activity observed alongside NNMT inhibition.
- Epigenetic regulation: Altered methylation patterns in adipose tissue associated with reduced lipogenic gene expression.
- Metabolic rate: Some models suggest resting metabolic rate increase comparable to low-level exercise training.
